Tottenham Hotspur vs Villarreal: prediction & betting odds 16 September 2025

The Matchday 1 fixture of the 2025/26 Champions League group stage between Tottenham (England) and Villarreal (Spain) will take place on September 16 at the Tottenham Hotspur Stadium in London. Tottenham vs. Villarreal: prediction and betting odds, statistics.

Tottenham

The Londoners finished only 17th in the Premier League last season. However, they secured a spot in the Champions League by winning the Europa League. In May, they defeated Manchester United 1-0 in the final of that tournament. The last time the English side participated in the Champions League was in the 2022/23 season, reaching the Round of 16, where they were stopped by Milan (0-1 on aggregate).

  • In their last 11 matches in this European competition, Tottenham has won only 3 times in regular time (3 draws and 5 losses).
  • No more than two goals were scored in 90 minutes in 6 of the last 8 Champions League games involving the Londoners.
  • At least one team failed to score in regular time in 7 of the previous 10 matches involving the English side in this tournament.

Predicted lineup for Tottenham (4-2-3-1)

Guglielmo Vicario – Djed Spence, Cristian Romero, Micky van de Ven, Pedro Porro – Joao Palhinha, Rodrigo Bentancur – Mohammed Kudus, Pape Sarr, Xavi Simons – Richarlison.

Defender Radu Dragusin and midfielders Yves Bissouma, James Maddison, and Dejan Kulusevski are currently sidelined due to injuries.

Villarreal

The Valencia-based team made it to the Champions League group stage thanks to a "gift" from UEFA in the form of an additional 5th spot for La Liga. The team finished 5th in the last La Liga season. Over the past 8 years, the club has only managed to qualify for the elite European competition twice. In the 2021/22 season, Villarreal reached the semi-finals, where they were defeated by Liverpool in both matches (0-2 and 2-3).

  • The team has not lost in regular time in 7 of their last 10 Champions League matches (5 wins and 2 draws).
  • Villarreal scored in 5 of their last 6 away matches in this tournament.
  • The Spaniards did not lose in the first half in 14 of their last 15 games in this European competition (5 wins and 9 draws).

Predicted lineup for Villarreal (4-3-3)

Luis Junior – Rafa Marin, Sergi Cardona, Santiago Mourino, Juan Foyth – Alberto Moleiro, Santi Comesana, Pape Gueye – Karl Etta Eyong, Nicolas Pepe, Tajon Buchanan.

Forwards Pau Cabanes and Gerard Moreno, as well as defenders Willy Kambwala and Logan Costa, are in the team's infirmary.

Referee

Rade Obrenovic (Slovenia)

Matches – 12 (International matches, 2024/25–2025/26);

Yellow cards shown (including second yellows) – 60;

Average yellow cards per match – 5;

Red cards shown – 1;

Average fouls per match – 23;

Penalties – 17%.

Match Prediction: Tottenham vs. Villarreal

Both teams rarely appear in the Champions League, so they are eager to make the most of this tournament, as it's uncertain if they will reach the group stage again next year. Interestingly, both clubs, if they qualify for the autumn stage of the Champions League, usually secure a spot in the European competitions in spring, thanks to their strong attacking play.

Tottenham has failed to score in only 3 of their last 19 home matches in the Champions League. Meanwhile, Villarreal has found the net in 5 of their last 6 away games in this tournament. Judging by the current form of both teams in their respective national leagues, the English and Spanish sides are likely to score again.

My prediction: Both teams to score – yes

Tottenham Hotspur — Villarreal betting tips 16 September 2025

These two sides returned from the international break with contrasting results, yet both Tottenham Hotspur and Villarreal average around two goals per game.

Tottenham delivered the over 2.5 almost single-handedly within the first 20 minutes of the second half against West Ham United, with Pape Sarr, Lucas Bergvall and Micky van de Ven all on the scoresheet. That spell also coincided with their opponents going down to ten men. Even so, it marked a third clean-sheet victory for Tottenham, and a second by a comfortable margin. They had to settle for a 2:0 against Manchester City, but you can hardly complain about that.

Villarreal, meanwhile, ran into an Atlético Madrid side desperate for their first win of the season. The team matched the hosts in the first half (both sides posting 0.87 xG), with Alberto Moleiro especially lively on the left, creating chances worth 0.70 xG. But it was all undone by a defensive lapse inside nine minutes, ruthlessly punished. Against lesser opposition such as Real Oviedo (2:0) or Girona (5:0), Villarreal have shown they can rack up goals with ease.

Tottenham, though, have Guglielmo Vicario between the posts, a keeper who has denied even Erling Haaland. That suggests a shootout is unlikely. And let’s not forget, Tottenham themselves rarely cut loose in last season’s triumphant Europa League campaign — five of their seven knockout ties finished under 2.5 goals. That’s the way we see this one going too.

Betting prediction
Total Under 2.5
Cf
Odds
107/100
Bet now

Tottenham Hotspur vs Villarreal Odds

Champions League: previous matches in the tournament

Tottenham Hotspur
The team hasn't played a game yet this season
Villarreal
The team hasn't played a game yet this season

Team lineups

The line-ups will be known a few hours before kick-off
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